MET OVEREXPRESSION Detail (hg38) (MET)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr7:116,312,459-116,436,396 View the variant detail on this assembly version. |
| hg38 | chr7:116,672,405-116,796,342 |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| skin melanoma | Vemurafenib | B |
Predictive
|
Supports
|
Resistance |
N/A
|
4 | 26359985 | Detail |
| uveal melanoma | Crizotinib | D |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
1 | 24140933 | Detail |
| skin melanoma | Vemurafenib | B |
Predictive
|
Does Not Support
|
Resistance |
N/A
|
3 | 23802768 | Detail |
| uveal melanoma | Selumetinib,Trametinib | D |
Predictive
|
Supports
|
Resistance | Somatic | 3 | 25952648 | Detail |
| stomach carcinoma | Rilotumumab | B |
Predictive
|
Does Not Support
|
Sensitivity/Response |
N/A
|
5 | 28958504 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Whole exome sequencing, transcriptome and methylome alterations in 48 melanoma samples with acquired... | CIViC Evidence | Detail |
| c-MET and ligand HGF were expressed by 6 uveal melanoma cell lines in-vitro. GNA-mutant cell lines (... | CIViC Evidence | Detail |
| FFPE tumours from patients enrolled in the BRIM2 (n = 59) and BRIM3 (n = 150) trials of vemurafenib ... | CIViC Evidence | Detail |
| In this study the authors screened for growth factors that elicited resistance in newly characterize... | CIViC Evidence | Detail |
| In this randomised, double-blind, placebo-controlled phase 3 trial, 609 patients with MET+ (expressi... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- MET
- Genome
- hg38
- Position
- chr7:116,672,405-116,796,342
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- OVEREXPRESSION
- Transcript 1 (CIViC Variant)
- ENST00000318493.6
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/621
Genome browser